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Synthesis, In-Silico Potential Enzymatic Target Predictions, Pharmacokinetics, Toxicity, Anti-Microbial and Anti-Inflammatory Studies of Bis-(2- methylindolyl) Methane Derivatives

Author(s):

Dnyaneshwar T Nagre, Suraj N. Mali, Bapu R. Thorat*, Swapnali A. Thorat, Atul R. Chopade, Mazhar Farooqui and Brijmohan Agrawal   Pages 1 - 17 ( 17 )

Abstract:


Background: The bis(indolyl)methanes (BIMs) scaffold is being reported for wide varieties of pharmacological profiles including anti-bacterial, anti-proliferative, anti-cancer, cytotoxic, insecticidal, analgesic, antioxidant, and anti-inflammatory agents.

Materials and Methods: A series of bis(indolyl)methanes have been synthesized using greener and new approach using the reaction of different substituted aldehydes and indole in presence of easily available and biodegradable base such as piperidine in acetic acid at room temperature and characterized with ultraviolet–visible spectrophotometry (UV–Vis or UV/Vis),Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy(NMR),etc. The antibacterial and antifungal activities were also carried out against Staphylococcus aureus (RCMB 000106) and Bacillis subtilis (RCMB 000107), as two Gram positive bacterial strains and Salmonella typhi and Escherichia coli (RCMB 000103), as two Gram negative bacterial strains. Fungal Species such as Candida Albicans, Penicillium chrysogenum, Aspergillus niger were also used for in-vitro antifungal evaluation. All our newly synthesized 14 compounds (4a-4n) were subjected for anti-inflammatory activity in-vitro and compared with known standard drug Aceclofenac.

Results and Conclusions: Our newly synthesized compounds showed good to moderate antibacterial agents, in-silico ADMET and anti-inflammatory profiles. We hope that our current study would aid future developments of bis(indolyl)methanes as antibacterial and anti-inflammatory agents.

Keywords:

Bis(indolyl)methanes, homogeneous catalysts, heterogeneous catalysts, biological activities, indole-3- carbaldehydes.

Affiliation:

Department of Chemistry, Rashtramata Indira Gandhi College, Jalna, Ahmednagar (M.S.), , Government college of Pharmacy, Karad, (M.S), , P.G. and Research Centre, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College, Jogeshwari, Mumbai, , Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, 415404, , Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, 415404, , Maulana Azad College, Aurangabad, (M.S.), , Department of Chemistry, J. E. S. College, Jalna, Ahmednagar (M.S.)



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