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A Review on Pancreatic Lipase Inhibitors from Natural Sources: A Potential Target for Obesity

[ Vol. 17 , Issue. 2 ]

Author(s):

Bency Baby T*, Murali R, Suriyaprakash TNK and Srinivasan N   Pages 83 - 97 ( 15 )

Abstract:


Background: Obesity is a worldwide lifestyle disorder and its incidence is growing at an alarming rate. Pancreatic lipase (PL) plays a key role in lipid metabolism and hence is a potential target for obesity treatment. There have been reports that many bioactive compounds from natural sources constitute a vast pool of PL inhibitors.

Objective: In search of natural pancreatic lipase inhibitors, the review summarizes the potential of natural products for their pancreatic lipase inhibitory activity.

Methods: In this review, the data obtained from literature search of various electronic databases and journal article publications have been reviewed.

Results: The pancreatic lipase inhibitory activities of 61 biological sources reviewed in this paper are backed by preclinical experimental evidence, either in vivo or in vitro.

Conclusion: This article can be used as a ready-to-use reference for therapeutic lead molecules from plants, marine and insect-derived natural products with PL inhibitory activity. The research is more focused on the discovery of more ingenious pancreatic lipase inhibitors with lesser consequences.

Keywords:

Pancreatic lipase, obesity, natural lipase inhibitors, orlistat, polyphenols, alkaloids.

Affiliation:

Department of Pharmacognosy, Al Shifa College of Pharmacy, Perinthalmanna, Kerala-679325, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Department of Pharmaceutics, Al Shifa College of Pharmacy, Perinthalmanna, Kerala-679325, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram

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