Bency Baby T*, Murali R, Suriyaprakash TNK and Srinivasan N Pages 83 - 97 ( 15 )
Background: Obesity is a worldwide lifestyle disorder and its incidence is growing at an alarming rate. Pancreatic lipase (PL) plays a key role in lipid metabolism and hence is a potential target for obesity treatment. There have been reports that many bioactive compounds from natural sources constitute a vast pool of PL inhibitors.
Objective: In search of natural pancreatic lipase inhibitors, the review summarizes the potential of natural products for their pancreatic lipase inhibitory activity.
Methods: In this review, the data obtained from literature search of various electronic databases and journal article publications have been reviewed.
Results: The pancreatic lipase inhibitory activities of 61 biological sources reviewed in this paper are backed by preclinical experimental evidence, either in vivo or in vitro.
Conclusion: This article can be used as a ready-to-use reference for therapeutic lead molecules from plants, marine and insect-derived natural products with PL inhibitory activity. The research is more focused on the discovery of more ingenious pancreatic lipase inhibitors with lesser consequences.
Pancreatic lipase, obesity, natural lipase inhibitors, orlistat, polyphenols, alkaloids.
Department of Pharmacognosy, Al Shifa College of Pharmacy, Perinthalmanna, Kerala-679325, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Department of Pharmaceutics, Al Shifa College of Pharmacy, Perinthalmanna, Kerala-679325, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram