Submit Manuscript  

Article Details


Molecular Docking Demonstration of the Liquorice Chemical Molecules on the Protease and ACE2 of COVID-19 Virus

[ Vol. 17 , Issue. 2 ]

Author(s):

─░smail Koyuncu*, Mustafa Durgun, Nuri Yorulmaz, Sahin Toprak, Ataman Gonel, Nihayet Bayraktar and Murat Caglayan   Pages 98 - 110 ( 13 )

Abstract:


Background: COVID-19 has spread rapidly in many countries of the world and poses a serious threat to global public health, yet no specific drug has been identified or currently available for its treatment. Since it may take years to design a drug for its treatment, the shortest and most effective way now is to screen the available drugs or active substances by molecular docking methods.

Objective: The aim of this study is to investigate the potential for use in COVID-19 treatment by investigating the inhibitory effects of Glycyrrhiza glabra, main active ingredients on COVID-19, main protease (SARS-CoV-2,), SARS-CoV-2 - ACE2 Complex and ACE-2 by molecular docking method, which are known to have antiviral effects on SARS-CoV.

Material and Methods: Molecular docking was performed by using Autodock 4.2 to analyse the probability of docking. Several compounds extracted from the root of the licorice plant (glycyrrhizic acid, glabridin, 6-azauridine, pyrazofurin and mycophenolic acid) were docked to inhibit COVID-19 Mpro and docking results were analysed by Autodock 4.2 and Biovia Discovery Studio Visualizer 2020. The evaluation was based on the docking score (binding energies) calculated by Autodock 4.2. Nelfinavir was used as standards for comparison.

Results: As a result of the study, the compounds of Glabridin in COVID-19 main protease (6LU7), ACE-2 (1R4L) and SARS-CoV-2, - ACE2 Complex (6LZG) have very low binding energy (-8.75 to - 7.64) and low potential to inhibition constant has been found.

Conclusion: These results suggest that Glabridin appeared to have the best potential to act as a COVID-19 Msup>pro inhibitor. However, further research is necessary to investigate their potential medicinal use.

Keywords:

Coronavirus, glycyrrhiza glabra, molecular docking, glabridin, protease, COVID-19.

Affiliation:

Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Department of Chemistry, Faculty of Arts and Sciences, Harran University, Sanliurfa, Department of Physics, Faculty of Arts and Sciences, Harran University, Sanliurfa, Department of Biology Faculty of Arts and Sciences, Harran University, Sanliurfa, Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Department of Medicinal Biochemistry, Yenimahalle Training and Research Hospital, Yildirim Beyazit University, Ankara

Graphical Abstract:



Read Full-Text article