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The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review

Author(s):

Kaviarasan Lakshmanan, Gowramma B*, Sravanthi B and Praveen T K   Pages 1 - 10 ( 10 )

Abstract:


Signal transducer and activator of transcription (STAT)3 is important transcription factors that are able to mediate or even drive cancer progression through hyperactivation or gain-of-function mutations. It plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. However, compelling evidence suggest that STAT3 is constitutively activated in many cancers and play a vital role in tumour growth and metastasis. Hyperactive STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukemia, melanoma or prostate cancer. Classical understanding of STAT functions is linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription. In this review, we discuss the functions and the roles of STAT3 signal in varied cancers.

Keywords:

STAT3, hyper activation, phosphorylation, cancer, solid tumor, gene transcription.

Affiliation:

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty (JSS Academy of Higher Education & Research-Deemed to be University, ooty), Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty (JSS Academy of Higher Education & Research-Deemed to be University, ooty), Department of Pharmacology, JSS College of Pharmacy, (JSS academy of higher education and research, Ooty) Udhagamandalam, Tamilnadu , Department of Pharmacology, JSS College of Pharmacy, (JSS academy of higher education and research, Ooty) Udhagamandalam, Tamilnadu



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