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The Preliminary Identification of Potential Vaccine Targets for SARSCoV2 and Computer-aided Synthesis ("Small Interfering RNA Design")

Author(s):

M Mouhcine*, Y Kadil and H Filali   Pages 1 - 5 ( 5 )

Abstract:


Coronaviruses constitute the subfamily Orthocoronavirinae, in the family Coronaviridae. Those viruses area positive-sense and very long single-stranded RNA viruses. Infection-related to SARS CoV2 was named as a pandemic disease by the World Health Organization on Mars 4, 2020. Several clinical trials have been stated to design the management process against this pathology and the most proposed drugs have been commercialized for other viral pathologies. Thus, no specific therapeutic protocol has been established. The objective of this work is the identification of potential vaccine targets of SARS CoV2. We aim to provide the potential therapeutic target that can inhibit the spread of the virus and identify miRNAs, and reminding proposals to improve the effectiveness of these vaccines. Our result showed that the potential molecules may specific regions in the viral ARN and exert an inhibitor activity against the viral transcription.

Keywords:

COVID19, ARN polymerase, Small interfering RNA, Vaccine, SARS CoV2

Affiliation:

Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca



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