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Antispermatogenic Effect of Piper betel Leaf Stalk Extract with Reference to Kinetic Studies of 17β-hydroxy Steroid Dehydrogenase Enzyme in Testes of Albino Rats

[ Vol. 15 , Issue. 1 ]

Author(s):

Naik A Govardhan , P Venkataramanaiah and C Changamma *   Pages 35 - 39 ( 5 )

Abstract:


Background: In the development and maintenance of male reproductive function and fertility, steroidogenesis plays a key role.

Methods: The aim of the present study was to investigate the effect of the betel leaf stalk extract on 17β-hydroxy steroid dehydrogenase activity levels.

Results: The observed elevation in testicular cholesterol levels may be due to decreased androgen production, which resulted in impaired spermatogenesis. The decreased steroidogenic enzyme 17β- HSD activity represents decreased androgen production by the extract administration. Reduction in enzyme active site density and Km value revealed that there was a reduction in enzyme-substrate affinities and rate of E-S complex breakdown in the administered rat testes.

Conclusion: The administration of betel leaf stalk extract resulted in decreased enzyme content probably through impaired synthesis.

Keywords:

17β-HSD, Betel leaf stalk extract, cholesterol, kinetic studies, spermatogenesis, steroidogenesis.

Affiliation:

Department of Zoology, S.V.University, Tirupati, A.P, Department of Zoology, S.V.University, Tirupati, A.P, Department of Zoology, S.V.University, Tirupati, A.P



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