Govardhan Naik Amgoth, P. Venkataramanaiah and Changamma Challa* Pages 36 - 40 ( 5 )
Background: In the development and maintenance of male reproductive function and fertility, steroidogenesis plays a key role.
Aims: The aim of the present study was to investigate the effect of the betel leaf stalk extract on 17β- hydroxy steroid dehydrogenase activity levels.
Methods: The observed elevation in testicular cholesterol levels may be due to decreased androgen production, which resulted in impaired spermatogenesis. The decreased steroidogenic enzyme 17β- HSD activity represents decreased androgen production by the extract administration. Reduction in enzyme active site density and Km value revealed that there was a reduction in enzyme-substrate affinities and rate of E-S complex breakdown in the administered rat testes.
Results & Conclusion: The administration of betel leaf stalk extract resulted in decreased enzyme content probably through impaired synthesis.
17β-HSD, Betel leaf stalk extract, cholesterol, kinetic studies, spermatogenesis, steroidogenesis.
Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, Department of Zoology, S.V. University, Tirupati, Andhra Pradesh