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Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates

[ Vol. 14 , Issue. 3 ]

Author(s):

Imdat Aygul, Fatma Yaylaci Karahalil*, Ozkan Danis, Ayşe Ogan and Sevgi Kolayli   Pages 226 - 232 ( 7 )

Abstract:


Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The IC50 values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting the highest activity. The inhibition values for urease ranged 22.30 µM to 39.00 µM, the highest activity being observed in C5.

Conclusion: Comparing the inhibitions with standard inhibitors of the enzymes, while the samples exhibited moderate inhibitions against hCA I, high inhibition was determined against urease.

Keywords:

Carbonic anhydrase, coumarin, inhibition, jack bean, synthesis compounds, urease.

Affiliation:

Faculty of Health Sciences, Department of Nutrition and Dietetics, Gumushane University, Gumushane, Department of Chemistry and Chemical Processing Technologies, Biochemistry Programme, Maçka Vocational School, Karadeniz Technical University, Trabzon, Faculty of Science, Department of Chemistry, Marmara University, Istanbul, Faculty of Science, Department of Chemistry, Marmara University, Istanbul, Faculty of Science, Department Of Chemistry, Karadeniz Technical University, Trabzon

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